Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP): The results of the clinical in situ trials indicate a short-term remineralization effect of CPP-ACP [1].
Powered toothbrushes, triclosan toothpaste, essential oil mouthwashes, xylitol chewing gum: The extent of available systematic review evidence is low. Although the few identified systematic reviews could be rated as of medium and high quality, the validity of their conclusions needs to be treated with caution, owing to high risk of selection bias in the reviewed trials [2].
Sugar-free chewing gum: The evidence suggests that sugar-free chewing gum has a caries-reducing effect. This effect can be ascribed to saliva stimulation through the chewing process, particularly when gum is used immediately after meals; the lack of sucrose and the inability of bacteria to metabolize polyols into acids [3].
Xylitol:The evidence identified in support of xylitol over sorbitol is contradictory [4]. The addition of xylitol to existing fluoride regimes may be beneficial in the prevention of caries [5].
References
[1] Yengopal V, Mickenautsch S. Caries preventive effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP): a meta-analysis. Acta Odontol Scand. 2009;67(6):321-332.Abstract
[2] Mickenautsch S, Yengopal V. Extent and quality of systematic review evidence related to minimum intervention in dentistry: essential oils, powered toothbrushes, triclosan, xylitol. Int Dent J. 2011;61(4):179-192.Abstract
[3] Mickenautsch S, Leal SC, Yengopal V, Bezerra AC, Cruvinel V. Sugar-free chewing gum and dental caries: a systematic review. J Appl Oral Sci. 2007;15(2):83-88.Abstract
[4] Mickenautsch S, Yengopal V. Effect of xylitol versus sorbitol: a quantitative systematic review of clinical trials. Int Dent J. 2012;62(4):175-188.Abstract
[5] Mickenautsch S, Yengopal V. Anticariogenic effect of xylitol versus fluoride - a quantitative systematic review of clinical trials. Int Dent J. 2012;62(1):6-20.Abstract
